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Content Higher prevalence in elderly - Multi-drug usage, lots of polypharmacy - Drug-disease interaction due to lots more comorbidities - Worse pharmacokinetics Only really seen with SSRI + SNRI. Mirtazapine does not appear to contribute in combination. Differences in management - Avoid combination antidepressant prescribing if possible - Follow guidelines regarding antidepressant switching. Most cases of

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